Furanic acid F2 (FuFA-F2) from Hevea brasiliensis latex: Toward a transition to an ecologically responsible production of bioactive molecules in a society that sustainably manages its natural resources

Encourage the transition to an ecologically responsible production of bioactive molecules (from sourcing to the production process) in a society that sustainably manages its natural resources is fundamental. The presence of potential bioactive molecule, in important quantity, in the rubber tree fresh latex, appears as an opportunity to support and highlight this ambition.

Indeed, a significant presence of furanic acid F2 (10, 13-epoxy-11-methyl-octadecan-10,12-dienoic, FuFA-F2) was evidenced in the latex of the rubber tree, which represents approximately 0.4% w/v of the latex, meaning that one liter of latex has a potential production of 4g of FuFA-F2. This molecule belongs to a family of lipid called furanic acids (FuFA) which are found in fruits, vegetables, oils, butter, fish, and recently raised a strong scientific curiosity, in particular for their health benefits (e.g.cardioprotective effects, obesity). The new requirements of consumers more sensitive to the origin and production conditions, lead manufacturers to move towards natural products that respect the environment and health. For example, in foodstuffs, the clean label meets the expectations of consumers who want to know the origin and composition of products.

Concomitantly, the world production of natural rubber, derived from Hevea brasiliensis latex, is very important (13.9 million tons in 2018, source IRSG) and the Southeast Asia supplies more than 90% of the world production, with Thailand being the world’s top supplier. In addition, 85% of the rubber cultivation is carried out by smallholders on a few hectares’ plantation (